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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

[Irbesartan in the treatment of arterial hypertension]

J Widimský1, J Zizka, T Haas

  • 1III. interní klinika 1. LF UK, Praha.

Vnitrni Lekarstvi
|January 14, 2005
PubMed

Insights

Irbesartan effectively lowers blood pressure in hypertensive patients. This angiotensin II receptor blocker also shows potential for treating chronic heart failure and diabetic complications.

Area of Science:

  • Cardiovascular Pharmacology
  • Nephrology

Background:

  • Irbesartan is an angiotensin II receptor blocker (ARB) with potential in cardiovascular diseases.
  • AT1 receptor blockers are being investigated for chronic heart failure treatment.

Purpose of the Study:

  • To evaluate the antihypertensive effect of Irbesartan.
  • To assess Irbesartan's impact on organ complications in hypertension and diabetes.

Main Methods:

  • A clinical study involving 139 patients with mild to moderate hypertension.
  • Twelve-week treatment with Irbesartan.
  • 24-hour blood pressure monitoring.

Main Results:

  • Significant reduction in systolic and diastolic blood pressure (p < 0.01).
  • Favorable 24-hour blood pressure control.
  • Positive effects on left ventricular hypertrophy and albuminuria observed in other studies.

Conclusions:

  • Irbesartan demonstrates a marked antihypertensive effect.
  • It may serve as an alternative for patients intolerant to ACE-inhibitors.
  • Potential benefits in arterial hypertension, chronic heart failure, and diabetic nephropathy.

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