Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early white matter changes in Wilson disease.

Archana Verma1, N N Singh, S Misra

  • 1Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-2.

The Journal of the Association of Physicians of India
|January 14, 2005
PubMed
Summary

This case report highlights a 12-year-old boy with cognitive decline and movement issues, diagnosed with Wilson disease. Early white matter changes on MRI are noted as a key feature in this pediatric neurological disorder.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Construction and Evaluation of a Pediatric Emergency Medicine Bootcamp for Graduating Emergency Medicine Residents.

AEM education and training·2026
Same author

A Review of Clinical Trial and Meta-Analyses of BP Treatment Strategies for Patients with Orthostatic Hypotension: Blood Pressure Management in Patients with Hypertension and Orthostatic Hypotension.

Current hypertension reports·2026
Same author

Absolute Quantification of microRNA Copies in Exosomes Using Real-Time PCR.

Current protocols·2026
Same author

Fluoride Exposure as a Possible Environmental Modifier of Idiopathic Parkinson's Disease: Insights from a Rural North Indian Cohort.

International journal of applied & basic medical research·2026
Same author

Occipital Needle-Like Spikes in a Visually Intact Child with Dystonia: Insights from Ambulatory EEG.

The Neurodiagnostic journal·2026
Same author

In vivo intratumoral heterogeneity in a dish: scalable forebrain organoid models of embryonal brain tumors for high-throughput personalized drug discovery.

Cancer communications (London, England)·2025

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Neuroimaging

Background:

  • Wilson disease is a rare genetic disorder causing copper accumulation.
  • Neurological and psychiatric symptoms are common, often presenting in adolescence or early adulthood.
  • Early diagnosis and treatment are crucial to prevent irreversible organ damage.

Observation:

  • A 12-year-old male presented with a year of cognitive decline and extrapyramidal symptoms.
  • Magnetic Resonance Imaging (MRI) revealed characteristic signal abnormalities.
  • These included increased T2-weighted signal intensity in the basal ganglia and supratentorial and infratentorial gray and white matter.

Findings:

  • Biochemical studies and MRI confirmed the diagnosis of Wilson disease.
  • The patient exhibited early-onset white matter changes, a less commonly emphasized finding.

Related Experiment Videos

  • MRI findings correlated with the clinical presentation of neurological impairment.

    • Implications:

    • This case underscores the importance of considering Wilson disease in pediatric patients with unexplained neurological and cognitive symptoms.
    • Early detection of white matter changes on MRI may aid in prompt diagnosis and management.
    • Understanding the spectrum of MRI findings in Wilson disease is vital for effective patient care and prognosis.