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[Homocystein and cardiovascular risk: is dosage useful?]

Ch Mathez1, L Trueb, R Darioli

  • 1Service de Médecine B, CHUV, Lausanne.

Praxis
|January 14, 2005
PubMed

Insights

High homocysteine levels are a risk factor for cardiovascular disease. Screening for elevated homocysteine is crucial, even without traditional risk factors, in patients with early atherosclerosis.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Hyperhomocysteinemia is an independent risk factor for atherothrombotic disease.
  • The mechanisms driving atherosclerosis progression in hyperhomocysteinemia are complex.
  • Premature atherosclerosis necessitates investigation into underlying causes.

Purpose of the Study:

  • To highlight the significance of screening for elevated homocysteine.
  • To emphasize the importance of considering hyperhomocysteinemia in patients with premature atherosclerosis.
  • To present a clinical case illustrating this diagnostic challenge.

Main Methods:

  • Clinical case report.
  • Review of relevant literature on hyperhomocysteinemia and atherosclerosis.
  • Diagnostic evaluation of a patient with premature atherosclerosis.

Main Results:

  • The presented case involves a patient with premature atherosclerosis.
  • Elevated homocysteine levels were identified as a potential contributing factor.
  • The absence of conventional risk factors underscored the need for broader screening.

Conclusions:

  • Screening for elevated homocysteine is vital in patients presenting with premature atherosclerosis.
  • Hyperhomocysteinemia should be considered even when traditional risk factors are absent.
  • Early detection and management of hyperhomocysteinemia can impact cardiovascular outcomes.

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