Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive effects of beta blockers.

J E Dimsdale1, R P Newton

  • 1Department of Psychiatry, University of California, San Diego.

Journal of Psychosomatic Research
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amino acid derivatives from Lucilia sericata excretions/secretions may contribute to the beneficial effects of maggot therapy via increased angiogenesis.

The British journal of dermatology·2009
Same author

Investigation of uremic analytes in hemodialysate and their structural elucidation from accurate mass maps generated by a multi-dimensional liquid chromatography/mass spectrometry approach.

Rapid communications in mass spectrometry : RCM·2009
Same author

Effects of stress on heart rate complexity--a comparison between short-term and chronic stress.

Biological psychology·2008
Same author

Online immobilized metal affinity chromatography/mass spectrometric analysis of changes elicited by cCMP in the murine brain phosphoproteome.

Rapid communications in mass spectrometry : RCM·2008
Same author

Fingerprint profile of Ginkgo biloba nutritional supplements by LC/ESI-MS/MS.

Phytochemistry·2008
Same author

The attenuating effect of personal mastery on the relations between stress and Alzheimer caregiver health: a five-year longitudinal analysis.

Aging & mental health·2007

Atenolol and metoprolol, common beta blockers, did not significantly impair neuropsychologic function or mood in hypertensive patients. Both drugs were associated with disturbing dreams, but fatigue complaints were similar to placebo.

Area of Science:

  • Cardiology
  • Pharmacology
  • Neuroscience

Background:

  • Hypertension is a prevalent cardiovascular condition often managed with beta-blockers.
  • Concerns exist regarding the potential neuropsychologic and mood-related side effects of beta-blocker therapy.
  • Atenolol and metoprolol are widely prescribed beta-blockers with distinct pharmacokinetic profiles.

Purpose of the Study:

  • To investigate the comparative effects of atenolol and metoprolol on neuropsychologic functioning.
  • To assess the impact of these beta-blockers on patient mood, sedation, and sleep patterns.
  • To determine if differential effects exist between atenolol and metoprolol regarding these outcomes.

Main Methods:

  • Double-blind, randomized trial involving 35 hypertensive patients.

Related Experiment Videos

  • Patients underwent a placebo washout period before receiving either atenolol or metoprolol for 4 weeks.
  • Neuropsychologic tests, mood assessments (Profile of Mood States), and sleep/sedation evaluations were conducted.

    • Main Results:

    • No consistent evidence of deleterious effects on neuropsychologic functioning with either beta-blocker.
    • No significant overall changes in mood were observed, though metoprolol showed a trend towards poorer mood.
    • Both drugs led to complaints of disturbing dreams, but no significant differences in deep sleep or sedation were found.
    • Fatigue complaints were substantial but equivalent to placebo, making attribution to medication difficult.

    Conclusions:

    • Atenolol and metoprolol do not appear to cause significant adverse neuropsychologic or mood effects in hypertensive patients.
    • Disturbing dreams are a potential side effect of both atenolol and metoprolol.
    • Further research may be needed to clarify the trend of poorer mood with metoprolol and the cause of fatigue.