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Prepubertal gynecomastia with lobular differentiation.

Malini Harigopal1, Melissa P Murray, Paul Peter Rosen

  • 1Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York 10021, USA.

The Breast Journal
|January 14, 2005
PubMed
Summary

This study details a rare case of prepubertal gynecomastia in a 19-month-old boy, characterized by unusual lobular differentiation. This finding, observed in the youngest patient to date, highlights a unique histological presentation.

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Area of Science:

  • Pediatric Endocrinology
  • Surgical Pathology
  • Developmental Biology

Background:

  • Gynecomastia, the enlargement of male breast tissue, is uncommon in infants and toddlers.
  • Prepubertal gynecomastia with lobular differentiation is an exceptionally rare condition, with limited documented cases.
  • Understanding the etiology and histological features of rare pediatric breast conditions is crucial for accurate diagnosis and management.

Observation:

  • A 19-month-old African American male presented with a unilateral, fatty breast mass noted shortly after birth.
  • Sonographic examination confirmed a fatty breast mass.
  • Microscopic analysis of the excised mass revealed florid gynecomastia with significant ductal hyperplasia and focal lobular differentiation.

Findings:

  • The case represents the fifth reported instance of prepubertal gynecomastia with lobular differentiation.

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  • This patient is the youngest individual documented with this specific histological finding.
  • The histological features indicate a complex developmental process within the male breast tissue.

    • Implications:

    • This case expands the understanding of rare pediatric breast abnormalities.
    • Further research into the developmental pathways of male breast tissue may be warranted.
    • Accurate histological diagnosis is essential for differentiating benign conditions from more serious pathologies in pediatric patients.