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[The inbred mouse strain STU. Development and properties (author's transl)]
Zeitschrift Fur Naturforschung. Section C, Biosciences
|March 1, 1979
Summary
The STU mouse strain, developed from a German white mouse colony, exhibits a high incidence of fibrosarcoma tumors. This inbred strain also shows C-type oncornaviruses and distinct immunological reactivity.
Area of Science:
- Genetics and Animal Models
- Oncology
- Immunology
Context:
- The STU mouse strain is a highly inbred model (up to 100 generations) originating from a German white mouse colony.
- Understanding the unique biological characteristics of established inbred mouse strains is crucial for biomedical research.
Purpose:
- To comprehensively describe the properties of the STU mouse strain.
- To detail the occurrence of tumors, C-type oncornaviruses, and immunological reactivity in this specific strain.
Summary:
- The STU mouse strain is characterized by a predominant fibrosarcoma incidence of approximately 23%.
- The study documents the presence of C-type oncornaviruses within this inbred mouse population.
- Immunological reactivity patterns specific to the STU strain are also detailed.
Impact:
- Provides essential baseline data for researchers utilizing the STU mouse strain in cancer and immunology studies.
- Highlights the STU strain as a valuable model for investigating fibrosarcoma development and viral oncogenesis.
- Contributes to the characterization of inbred mouse models for genetic and disease research.