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How to prevent steroid induced osteoporosis
1Royal North Shore Hospital, St Leonards, Sydney, Australia 2065. sambrook@med.usyd.ed.au
Annals of the Rheumatic Diseases
|January 14, 2005
Summary
The primary prevention for corticosteroid osteoporosis involves potent oral bisphosphonates like alendronate or risedronate. Calcium and vitamin D supplements can help prevent bone loss in patients on long-term low-dose corticosteroids.
Area of Science:
- Endocrinology
- Bone Metabolism
Background:
- Corticosteroid therapy is associated with significant bone loss and increased fracture risk.
- Osteoporosis is a common and serious side effect of long-term corticosteroid use.
Purpose of the Study:
- To outline the best strategies for preventing corticosteroid-induced osteoporosis.
- To review current and emerging therapeutic options for bone protection.
Main Methods:
- Review of current clinical guidelines and relevant literature.
- Analysis of pharmacological interventions for bone density preservation.
Main Results:
- Potent oral bisphosphonates (alendronate, risedronate) are the first-line treatment for prevention.
- Intravenous bisphosphonates are an alternative for patients with oral intolerance.
- Calcium and vitamin D supplementation may prevent further bone loss in patients on chronic low-dose corticosteroids.
Conclusions:
- Effective prevention and management strategies are crucial for patients on corticosteroid therapy.
- Parathyroid hormone therapy shows promise as a future treatment option for corticosteroid osteoporosis.