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Rapid Molecular Detection and Differentiation of Influenza Viruses A and B
05:38

Rapid Molecular Detection and Differentiation of Influenza Viruses A and B

Published on: January 30, 2017

Update: influenza activity--United States, 2004-05 season

    MMWR. Morbidity and Mortality Weekly Report
    |January 14, 2005
    PubMed

    Insights

    Influenza activity increased in the US starting mid-December, with 45 states reporting infections. An Investigational New Drug protocol will allow the use of additional imported influenza vaccine due to supply shortages.

    Area of Science:

    • Public Health
    • Epidemiology
    • Virology

    Background:

    • Influenza activity in the United States was low from October to early December 2004.
    • Activity began to increase steadily in mid-December, indicating the season had not yet peaked.
    • Laboratory-confirmed influenza infections were reported across 45 states.

    Purpose of the Study:

    • To summarize influenza activity in the US from October 3, 2004, to January 1, 2005.
    • To provide information on the availability of additional influenza vaccine.
    • To address the influenza vaccine supply shortage.

    Main Methods:

    • Surveillance data analysis for influenza activity.
    • Antigenic characterization of circulating influenza viruses.
    • Description of the procurement and administration of imported influenza vaccine.

    Main Results:

    • Influenza activity increased significantly after mid-December 2004.
    • Circulating influenza viruses were antigenically well-matched to the 2004-05 vaccine strains.
    • 1.2 million doses of inactivated influenza vaccine were purchased from GlaxoSmithKline (GSK) to supplement the domestic supply.

    Conclusions:

    • The 2004-05 influenza season activity increased after mid-December.
    • A vaccine supply shortage necessitated the use of imported GSK vaccine under an Investigational New Drug (IND) protocol.
    • The antigenic match between vaccine strains and circulating viruses was favorable.

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