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Related Experiment Videos

Reactive endplate marrow changes: a systematic morphologic and epidemiologic evaluation.

Michael Karchevsky1, Mark E Schweitzer, John A Carrino

  • 1Department of Radiology, Hahnemann University Hospital, Broad and Vine Streets, Philadelphia, PA 19102, USA. michael.karchevsky@jefferson.edu

Skeletal Radiology
|January 14, 2005
PubMed
Summary
This summary is machine-generated.

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Vertebral endplate changes, particularly Modic type II, are common with aging and more prevalent in males. These degenerative changes predominantly affect the anterior aspects of the L4-L5 and L5-S1 levels.

Area of Science:

  • Radiology
  • Orthopedics
  • Spine Imaging

Background:

  • Vertebral endplate changes are common findings in spinal imaging.
  • Understanding their prevalence and associations is crucial for diagnosing degenerative disc disease.

Purpose of the Study:

  • To evaluate the morphology and location of vertebral endplate changes.
  • To analyze their association with age, gender, and body mass index (BMI).

Main Methods:

  • 100 lumbar spines were evaluated using 1.5 T MRI (T1-weighted, T2-weighted/STIR).
  • Endplate bone marrow abnormalities (Modic types I, II, III) were classified and localized.
  • Associations with age, gender, and BMI were analyzed.

Main Results:

Related Experiment Videos

  • Modic type II changes were most frequent, followed by type I and type III.
  • L4-L5 and L5-S1 levels were most commonly affected, particularly the anterior endplate.
  • Endplate changes were significantly associated with increasing age and male gender, but not BMI.

    • Conclusions:

    • Vertebral endplate marrow changes, especially the fatty pattern (Modic type II), are common and linked to aging.
    • These degenerative changes predominantly occur anteriorly at the L4-L5 and L5-S1 levels.
    • While associated with age and male gender, endplate changes were not correlated with body mass index.