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[18F]FDOPA PET and clinical features in parkinsonism due to manganism

Brad A Racette1,2, Jo Ann Antenor1, Lori McGee-Minnich1,2

  • 1Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 14, 2005
PubMed

Insights

Manganese exposure can cause parkinsonism with reduced dopamine transporter activity, similar to Parkinson's disease (PD). This case highlights potential overlaps in clinical and imaging findings between manganese-associated parkinsonism and PD.

Area of Science:

  • Neuroscience
  • Toxicology
  • Radiology

Background:

  • Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder.
  • Manganese exposure is known to cause a distinct parkinsonian syndrome.

Observation:

  • A patient presented with parkinsonism and elevated blood manganese levels due to hepatic dysfunction.
  • Positron emission tomography with 6-[18F]fluorodopa ([18F]FDOPA PET) revealed reduced uptake in the posterior putamen.
  • T1-weighted magnetic resonance imaging (MRI) showed increased signal in the globus pallidum interna.

Findings:

  • Elevated manganese exposure may correlate with reduced striatal [18F]FDOPA uptake.
  • MRI may identify specific abnormalities in the internal globus pallidus.

Implications:

  • Manganese-associated parkinsonism may share clinical and pathophysiological features with idiopathic PD.
  • This case underscores the importance of considering manganese toxicity in parkinsonism diagnosis.
  • Neuroimaging, including [18F]FDOPA PET and MRI, can aid in differentiating these conditions.

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