Related Experiment Video
Updated: Aug 20, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
Published on: June 26, 2019
Functional variation of HIV-1 Rev Response Element in a longitudinally studied cohort
Angsana Phuphuakrat1, Robert M Paris, Sorachai Nittayaphan
1Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Abstract:
We showed previously that HIV-1 Rev Response Element (RRE) contains a certain degree of structural variation, and in a set of limited samples, RRE from HIV-1 natural isolates were found to have functional variability. The significance of the RRE heterogeneity is addressed further by analyzing the functional variation of RREs in a longitudinal cohort. While the RRE activity at early time points was not a good predictor of disease outcome, the RRE activity at late time points was correlated with rates of CD4+ count decline. These data suggest that RRE heterogeneity may be important in viral pathogenesis and disease progression.
Related Concept Videos
Viral Mutations
Size and Structure of Viral Genomes
Genetic Variation
Genes exist in different versions called alleles, which...

