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Hemostasis and thyroid diseases revisited.

M Franchini1

  • 1Immunohematology and Transfusion Service, Hemophilia Center, Hospital of Verona ,Verona, Italy. massimo.franchini@mail.azosp.vr.it

Journal of Endocrinological Investigation
|January 15, 2005
PubMed
Summary

This review revises hemostatic abnormalities in thyroid disease. Hyperthyroidism generally shows a hypercoagulable state, while hypothyroidism and thyroid cancer

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Area of Science:

  • Endocrinology and Hematology
  • Thyroidology
  • Hemostasis Research

Background:

  • Thyroid diseases are associated with hemostatic abnormalities.
  • Traditional views link hyperthyroidism to hypercoagulability and hypothyroidism to hypocoagulability.
  • Recent literature requires critical revision of these associations.

Purpose of the Study:

  • To critically revise the hemostatic balance in thyroid disorders based on recent literature.
  • To analyze primary hemostasis, coagulation factors, and the fibrinolytic system in various thyroid conditions.

Main Methods:

  • Literature review of recent studies on thyroid disease and hemostasis.
  • Analysis of hemostatic profiles, including primary hemostasis, coagulation, and fibrinolysis.
  • Critical evaluation of existing data, acknowledging limitations like small patient numbers and contradictory results.

Main Results:

  • Hyperthyroidism is generally associated with a hypercoagulable state.
  • Hemostatic profiles in hypothyroidism and thyroid cancer are dependent on disease severity.
  • Existing data, though sometimes contradictory, supports these general trends.

Conclusions:

  • Hyperthyroidism is linked to an increased risk of blood clot formation.
  • The hemostatic status in hypothyroidism and thyroid cancer is variable and severity-dependent.
  • Further research with larger cohorts is needed to clarify contradictory findings.

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