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Su-11248 Sugen

Kathleen M Sakamoto1

  • 1Division of Hematology-Oncology, Mattel Children's Hospital, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095-1752, USA. kms@ucla.edu

Current Opinion in Investigational Drugs (London, England : 2000)
|January 15, 2005
PubMed

Insights

SUGEN is developing SU-11248, an oral tyrosine kinase (TK) inhibitor targeting platelet-derived growth factor and other TK pathways for cancer treatment. Phase III trials for gastrointestinal stromal tumors and renal cell carcinoma were ongoing in October 2003.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Tyrosine kinase (TK) signaling pathways play a critical role in cancer cell proliferation and survival.
  • Inhibitors targeting TKs are a promising strategy for anticancer drug development.
  • SU-11248 is an orally active small molecule designed to inhibit multiple TKs.

Purpose of the Study:

  • To evaluate SU-11248, an orally active tyrosine kinase inhibitor, as a potential anticancer therapeutic.
  • To assess the efficacy of SU-11248 in patients with gastrointestinal stromal tumors (GIST) and renal cell carcinoma (RCC).

Main Methods:

  • Development of SU-11248, an orally active inhibitor targeting platelet-derived growth factor tyrosine kinase (TK) and other TK signaling pathways.
  • Initiation of Phase III clinical trials to evaluate SU-11248 in patients with GIST and RCC.

Main Results:

  • By October 2003, Phase III trials for gastrointestinal stromal tumors were underway.
  • By October 2003, Phase III trials for renal cell carcinoma were underway.

Conclusions:

  • SU-11248 demonstrates potential as an anticancer agent targeting key TK signaling pathways.
  • Ongoing Phase III trials will determine the clinical utility of SU-11248 for GIST and RCC treatment.

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