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Reference values for serum silicon in adults.

Emmanuel Bissé1, Thomas Epting, Annette Beil

  • 1Department of Clinical Chemistry, University Hospital Freiburg, D-79106 Freiburg, Germany. bisse@med1.ukl.uni-freiburg.de

Analytical Biochemistry
|January 15, 2005
PubMed
Summary

Serum silicon levels are crucial for human health, particularly bone and connective tissue. This study establishes reference values, revealing significant age and sex-related variations in silicon concentration.

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Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Silicon is an essential nutrient vital for human biology.
  • It plays a key role in the formation of bone, cartilage, and connective tissues.
  • Establishing reference values for serum silicon is challenging due to a lack of data.

Purpose of the Study:

  • To establish reference values for serum silicon concentrations in apparently healthy individuals.
  • To investigate the age and sex dependency of serum silicon levels.

Main Methods:

  • Serum silicon concentrations were measured in 1325 healthy subjects aged 18-91 years.
  • Atomic absorption spectrometry was employed for precise silicon determination.
  • Statistical analysis was performed to identify age and sex-dependent trends.

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Main Results:

  • Serum silicon medians exhibited statistically significant variations based on age and sex.
  • In men, silicon levels decreased with age, from 9.5 µmol/L (18-59 years) to 8.5 µmol/L (60-74 years).
  • Women showed a complex pattern: an increase from 10.00 µmol/L (18-29 years) to 11.10 µmol/L (30-44 years), followed by a decrease to 9.23 µmol/L (45-59 years).
  • In individuals over 74 years, median serum silicon was 7.70 µmol/L for men and 8.00 µmol/L for women.

Conclusions:

  • Serum silicon concentrations demonstrate a notable decrease with age, particularly in women.
  • These findings provide essential reference values for future research on silicon's health effects.
  • Understanding silicon's physiological role and concentration variations is critical for medical and nutritional science.