Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A computational perspective on migraine aura.

M A Dahlem1, E P Chronicle

  • 1Department of Neurology II, Otto-von-Guericke University, Magdeburg, Germany. dahlem@ifn-magdeburg.de

Progress in Neurobiology
|January 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interplay of time-delayed feedback control and temporally correlated noise in excitable systems.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2009
Same author

Anticonvulsants in migraine prophylaxis: a Cochrane review.

Cephalalgia : an international journal of headache·2008
Same author

Efficient control of transient wave forms to prevent spreading depolarizations.

Journal of theoretical biology·2008
Same author

Objective assessment of cortical excitability in migraine with and without aura.

Cephalalgia : an international journal of headache·2006
Same author

Cognitive function is not impaired in people with a long history of migraine: a blinded study.

Cephalalgia : an international journal of headache·2006
Same author

Controversies in headache.

Cephalalgia : an international journal of headache·2004
Same journal

Deletion of Fbxo25 causes excessive repetitive behavior, impaired recognition memory, reduced dendritic complexity, and aberrant protein expression in mice.

Progress in neurobiology·2026
Same journal

Neuropsychiatric Disease Mechanisms and Interventions. from 22q11.2 Deletion Syndrome Experimental Studies.

Progress in neurobiology·2026
Same journal

REM sleep as a dummy-model of the world: A theoretical framework.

Progress in neurobiology·2026
Same journal

CA3 transiently modulates spatial representation in CA1.

Progress in neurobiology·2026
Same journal

Love, death, and oxytocin: In memory of Larry Young.

Progress in neurobiology·2026
Same journal

Assessing peripheral oxytocin and cortisol levels and epigenetic variations of oxytocin receptor and glucocorticoid receptor genes in school-aged preterm-born children.

Progress in neurobiology·2026
See all related articles

Computational modeling of migraine aura reveals insights into visual disturbances. This approach, based on cortical organization and wave propagation, aligns with patient descriptions and offers testable predictions for future research.

Area of Science:

  • Neuroscience
  • Computational Biology
  • Medical Imaging

Background:

  • Migraine aura, particularly visual aura, presents as a unilateral hallucination with specific patterns like fortification figures and scotomas.
  • Historical and recent theories on migraine aura pathophysiology exist, but a unified mechanistic explanation remains elusive.

Purpose of the Study:

  • To develop and validate a computational model for migraine aura.
  • To explore the underlying principles of cortical organization and wave propagation in aura generation.
  • To bridge the gap between theoretical models and empirical observations of migraine aura.

Main Methods:

  • Review of historical and contemporary theories on migraine aura pathophysiology.
  • Development of a computational model based on principles of cortical organization.

Related Experiment Videos

  • Simulation of active wave propagation in an excitable medium to mimic aura phenomena.
  • Comparison of model outputs with patient-reported visual aura descriptions and drawings.

    • Main Results:

    • The computational model successfully reproduced key characteristics of visual migraine aura, including pattern evolution and spread.
    • Demonstrated correspondences between the model's properties and known aspects of aura pathophysiology.
    • Simulations generated results consistent with clinical descriptions and visual representations of aura by migraine sufferers.

    Conclusions:

    • Computational modeling provides a powerful framework for understanding migraine aura.
    • The model offers testable predictions that can guide empirical research.
    • Model-based research can enhance the recording of aura phenomena and deepen the understanding of various aura types and their initiation.