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Related Experiment Videos

[Cryptococcosis: presentation of 26 cases].

E Pedrol1, J Mallolas, J M González-Clemente

  • 1Servico de Enfermedades Infecciosas, Hospital Clínic i Provincial, Barcelona.

Medicina Clinica
|March 14, 1992
PubMed
Summary

The incidence of cryptococcosis has increased due to acquired immunodeficiency syndrome (AIDS). In AIDS patients, cryptococcosis presents as severe, disseminated, and often asymptomatic infections requiring maintenance therapy to prevent relapse.

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunology

Context:

  • Cryptococcosis incidence has risen with the advent of acquired immunodeficiency syndrome (AIDS).
  • AIDS significantly alters the clinical presentation and progression of cryptococcosis.
  • This study examines cryptococcosis in the context of AIDS, reviewing changes in its manifestation and outcomes.

Purpose:

  • To review the clinical and evolutive changes in cryptococcosis associated with acquired immunodeficiency syndrome (AIDS).
  • To analyze the clinical presentation, diagnostic findings, and treatment outcomes of cryptococcosis in patients with and without AIDS.

Summary:

  • A retrospective study (1985-1990) analyzed 26 patients with cryptococcosis, 20 of whom had human immunodeficiency virus (HIV).
  • AIDS patients presented with more frequent positive blood cultures, higher serologic titers, and less meningeal involvement, often in advanced immunodeficiency stages.

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  • Treatment with amphotericin B and 5-fluorocytosine was common, with relapses observed in AIDS patients, necessitating maintenance therapy.

    • Impact:

    • Highlights the increased prevalence and altered clinical spectrum of cryptococcosis in the era of AIDS.
    • Underscores the need for vigilant diagnosis and management, including maintenance therapy, for cryptococcosis in immunocompromised individuals.
    • Provides insights into the diagnostic and therapeutic challenges posed by cryptococcosis in advanced HIV infection.