Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Time-independent point-spread function for NMR microscopy.

E W McFarland1

  • 1Francis Bitter National Magnet Laboratory, Massachusetts Institute of Technology, Cambridge.

Magnetic Resonance Imaging
|January 1, 1992
PubMed
Summary

Nuclear Magnetic Resonance (NMR) microscopy resolution is analyzed using point-spread function (PSF) and modulation transfer function (MTF). Diffusion limits on spatial resolution are less stringent than previously thought.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Manipulation of gold nanoparticles: influence of surface chemistry, temperature, and environment (vacuum versus ambient atmosphere).

Langmuir : the ACS journal of surfaces and colloids·2008
Same author

Combinatorial electrochemical synthesis and characterization of tungsten-based mixed-metal oxides.

Journal of combinatorial chemistry·2002
Same author

Chemically induced electronic excitations at metal surfaces.

Science (New York, N.Y.)·2001
Same author

31P NMR spectroscopy of developing cartilage produced from chick chondrocytes in a hollow-fiber bioreactor.

Magnetic resonance in medicine·2000
Same author

Cartilage formation in a hollow fiber bioreactor studied by proton magnetic resonance microscopy.

Matrix biology : journal of the International Society for Matrix Biology·1999
Same author

A radiobiological probe for simultaneous NMR spectroscopy and 192Ir gamma irradiation of Saccharomyces cerevisiae.

Biochemical and biophysical research communications·1997

Area of Science:

  • Biophysics
  • Medical Imaging

Background:

  • Nuclear Magnetic Resonance (NMR) microscopy offers high-resolution imaging.
  • Understanding factors limiting NMR microscopy resolution is crucial for advancing biological and medical imaging.

Purpose of the Study:

  • To analyze NMR microscopy resolution using point-spread function (PSF) and modulation transfer function (MTF).
  • To investigate the impact of spin diffusion on spatial resolution limits in NMR microscopy.
  • To re-evaluate previous estimates of diffusion-imposed resolution limits.

Main Methods:

  • Analysis of NMR microscopy resolution via PSF(r) and MTF(k).
  • Development of a general framework applicable to spin warp and projection reconstruction imaging.
  • Investigation of incoherent spin motion and its effect on spatial resolution.

Related Experiment Videos

Main Results:

  • Diffusion-dependent blurring can be minimized, suggesting less stringent practical resolution limits than previously estimated.
  • Irreversible loss of spin coherence due to diffusion occurs faster than physical displacement, reducing its impact on signal frequency/phase.
  • Resolution, measured by PSF and MTF width, is independent of signal acquisition time.

Conclusions:

  • The PSF-MTF framework provides a general method for analyzing NMR microscopy resolution.
  • Diffusion imposes less severe practical limits on spatial resolution than previously believed.
  • Signal loss from diffusion contributes to signal-to-noise ratio limitations in resolution.