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Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
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Atomoxetine for the treatment of pediatric nocturnal enuresis

Jess P Shatkin1

  • 1Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. shatkinjp@upmc.edu

Journal of Child and Adolescent Psychopharmacology
|January 15, 2005
PubMed

Insights

Four children with attention deficit hyperactivity disorder (ADHD) and nocturnal enuresis found their bedwetting resolved when treated with atomoxetine for ADHD. This medication offers a potential new avenue for treating comorbid ADHD and enuresis.

Area of Science:

  • Pediatric medicine
  • Neurology
  • Psychiatry

Background:

  • Current treatments for pediatric nocturnal enuresis include behavioral methods and medications like antidiuretic hormone analogs, tricyclic antidepressants, and anticholinergics.
  • A significant portion of children do not fully respond to existing enuresis treatments, even with optimal management.
  • Attention deficit hyperactivity disorder (ADHD) is a common comorbidity in children with nocturnal enuresis.

Observation:

  • This report details four pediatric cases with comorbid ADHD and nocturnal enuresis.
  • Each child received atomoxetine for their ADHD symptoms.
  • A notable observation was the unexpected resolution of nocturnal enuresis in all four patients following atomoxetine treatment.

Findings:

  • Atomoxetine, a medication primarily used for ADHD, demonstrated a serendipitous positive effect on nocturnal enuresis.
  • The resolution of enuresis occurred in children who were treated for ADHD with atomoxetine.
  • This suggests a potential link between ADHD treatment and enuresis improvement.

Implications:

  • Atomoxetine may represent a novel therapeutic option for children experiencing both ADHD and nocturnal enuresis.
  • Further research is warranted to explore the efficacy and mechanisms of atomoxetine in treating comorbid ADHD and enuresis.
  • This finding could lead to improved management strategies for children with complex neurodevelopmental and urological conditions.

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