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Related Experiment Videos

Aripiprazole for maladaptive behavior in pervasive developmental disorders.

Kimberly A Stigler1, David J Posey, Christopher J McDougle

  • 1Department of Psychiatry, Indiana University School of Medicine and the James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202, USA.

Journal of Child and Adolescent Psychopharmacology
|January 15, 2005
PubMed
Summary

Aripiprazole effectively treated maladaptive behaviors in five youths with pervasive developmental disorders (PDD). The medication was well-tolerated in this short-term study, showing promising results for PDD symptom management.

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Area of Science:

  • Child and Adolescent Psychiatry
  • Neurodevelopmental Disorders
  • Pharmacological Treatments

Background:

  • Pervasive Developmental Disorders (PDD) encompass a range of neurodevelopmental conditions.
  • Maladaptive behaviors are common challenges in individuals with PDD.
  • Exploring novel therapeutic agents for PDD is crucial.

Observation:

  • A naturalistic, open-label trial was conducted on five pediatric patients diagnosed with PDD.
  • Aripiprazole was administered at dosages ranging from 10-15 mg/day for a mean duration of 12 weeks.
  • Patient response was assessed using the Clinical Global Impressions-Improvement (CGI-I) scale.

Findings:

  • All five participants showed significant improvement, with CGI-I ratings of "much improved" or "very much improved."

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  • Aripiprazole was generally well-tolerated, with no reported extrapyramidal symptoms or significant cardiovascular changes.
  • Mild somnolence was observed in two patients; weight changes were variable, with some experiencing loss possibly due to prior medication discontinuation.

    • Implications:

    • This case series suggests aripiprazole may be effective for managing maladaptive behaviors in pediatric PDD.
    • The preliminary findings indicate a favorable short-term tolerability profile.
    • Further research, including larger controlled trials, is warranted to confirm these initial observations and establish long-term efficacy and safety.