[Frontotemporal dementia: tau mutations, deposition, and molecular mechanisms of neuronal cell death]

Exonic and intronic tau mutations have been described in a number of families of frontotemporal dementia and parkinsonism linked to chromosome 17. Most of missense mutations alter the ability of tau to promote microtubule assembly, whereas others influence splicing of exon10 and change the ratio of 3Rtau to 4Rtau isoform. In either case, filamentous hyperphosphorylated tau pathology in neurons and glial cells was observed in affected brains. These observations suggest that the effects of tau mutations may induce its hyperphosphorylation and accumulation, resulting in cell death. In sporadic tauopathies, decreased levels of 3R tau mRNA were detected not only in severely affected cases with progressive supranuclear palsy or corticobasal degeneration but also in cases with Alzheimer's disease or Pick's disease. In addition, levels of 3R tau mRNA were closely correlated with levels of neurofilament mRNA. These results suggest that decreased levels of 3R tau mRNA in sporadic tauopathies may be due to degeneration and loss of neurons that express 3R tau isoforms. In tauopathies, neuronal cell death may occur with multiple defects or abnormalities arisen directly or indirectly from hyperphosphorylation of tau and formation of oligomer or filamentous tau.