Related Experiment Video

Updated: Aug 20, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

[Pulmonary infection in immunocompromised hosts]

Tsuneo Suzuki1, Takeo Kawashiro

  • 1National Hospital Organization Higashi Saitama Hospital, Saitama, Japan.

Nihon Geka Gakkai Zasshi
|January 18, 2005
PubMed

Insights

Surgical lung resection is necessary for specific pulmonary infections, including those in immunocompromised patients, drug-resistant cases, and infections with no effective treatments like Aspergillus and multidrug-resistant tuberculosis.

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Surgical Oncology

Background:

  • Most pulmonary infections are treatable with antimicrobial agents.
  • Certain complex infections necessitate surgical intervention.
  • Advancements in cancer therapy increase immunocompromised patient populations.

Purpose of the Study:

  • To outline the indications for surgical lung resection in pulmonary infections.
  • To discuss specific challenging microbial pathogens requiring surgical management.
  • To highlight the physician's perspective on these complex cases.

Main Methods:

  • Review of clinical scenarios requiring surgical lung resection for pulmonary infections.
  • Discussion of cases involving immunocompromised patients.
  • Analysis of infections with antimicrobial resistance or lack of effective drugs.

Main Results:

  • Surgical lung resection is indicated for pulmonary infections in immunocompromised patients.
  • Infections caused by drug-resistant microorganisms, such as multidrug-resistant tuberculosis and Aspergillus species, often require surgery.
  • Massive hemoptysis from Aspergillus infections in prior tuberculosis sites necessitates resection.

Conclusions:

  • Surgical lung resection is a critical treatment modality for select pulmonary infections.
  • Indications include immunocompromised status, antimicrobial resistance, and untreatable pathogens.
  • Prompt surgical intervention is vital for managing severe complications like hemoptysis.

More Related Videos

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...