Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Epimorphin expression in interstitial pneumonia.

Yasuhiro Terasaki¹, Yuh Fukuda, Moritaka Suga

¹Department of Cell Pathology, Postgraduate School of Medicine, Kumamoto University, Kumamoto, Japan. terayasu@kaiju.medic.kumamoto-u.ac.jp

Respiratory Research

|January 18, 2005

Summary

Epimorphin aids lung tissue repair in nonspecific interstitial pneumonia (NSIP) by promoting healing in fibrotic lesions. It may induce matrix metalloproteinase 2, a key factor in lung remodeling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prognostic impact of thyroid transcription factor-1 expression and the efficacy of carboplatin plus (nab-) paclitaxel in non-squamous non-small cell lung cancer complicated with idiopathic interstitial pneumonias.

Translational lung cancer research·2026

Same author

Development and Clinical Application of a Deep Learning-Based AI Support Model for Endometrial Cancer Cytology.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi·2026

Same author

A proposed pathological diagnosis flowchart for adult interstitial lung disease with transbronchial lung cryobiopsy: Position paper from the Japanese research group on diffuse lung disease.

Respiratory investigation·2026

Same author

An integrated system from microscopy to AI for real-time object detection in endometrial cytology.

Journal of pathology informatics·2026

Same author

Drug-induced Interstitial Lung Disease with a Hypersensitivity Pneumonitis Pattern Following Pembrolizumab Plus Epirubicin and Cyclophosphamide Therapy: First Report with Pathological Findings.

Internal medicine (Tokyo, Japan)·2025

Same author

Association of the expression of 5-FU biomarkers with aging and prognosis in elderly patients with lung cancer treated with S-1 adjuvant chemotherapy: Follow-up results of the Setouchi Lung Cancer Group Study 1201.

Molecular and clinical oncology·2025

Area of Science:

Pulmonary Medicine
Cell Biology
Biochemistry

Background:

Epimorphin's role in embryonic development and tissue repair is established.
Previous studies suggested epimorphin's involvement in repairing pulmonary fibrosis in mice.

Purpose of the Study:

To investigate epimorphin expression and function in human lung fibrosis.
To clarify epimorphin's role in nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP).

Main Methods:

Analyzed epimorphin expression in normal, NSIP, and UIP human lung tissues using Northern and Western blotting.
Utilized immunohistochemistry to determine epimorphin localization in fibrotic lesions.
Assessed the effect of recombinant epimorphin on human alveolar epithelial cells in vitro, including matrix metalloproteinase 2 (MMP-2) expression.

Related Experiment Videos

Main Results:

Epimorphin expression was significantly higher in NSIP lungs compared to control and UIP lungs.
Epimorphin was localized to mesenchymal cells and extracellular matrix in early fibrotic lesions of NSIP.
Recombinant epimorphin induced matrix metalloproteinase 2 (MMP-2) expression in human alveolar epithelial cells.

Conclusions:

Epimorphin plays a role in the repair of pulmonary fibrosis in NSIP.
Epimorphin may contribute to lung repair by inducing MMP-2, a crucial enzyme for tissue remodeling.