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Related Experiment Videos

Does the AD7c-NTP locus encode a protein?

Jan Ole Kriegs1, Jürgen Schmitz, Wojciech Makalowski

  • 1Institute of Experimental Pathology, ZMBE, University of Münster, Von-Esmarch-Str. 56, Münster, Germany.

Biochimica Et Biophysica Acta
|January 18, 2005
PubMed
Summary
This summary is machine-generated.

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The Alzheimer's disease-associated AD7c-NTP protein may not exist. Reassessment of previous findings is needed due to inconsistencies with genetic data.

Area of Science:

  • Neuroscience
  • Genetics
  • Biochemistry

Background:

  • AD7c-NTP, a protein encoded by Alu repetitive elements, was reported as over-expressed in Alzheimer's disease (AD) brains.
  • This finding led to the development of diagnostic assays for AD.

Purpose of the Study:

  • To re-evaluate the existence of the AD7c-NTP gene and protein.
  • To compare the published cDNA sequence with EST and genomic data.

Main Methods:

  • Bioinformatic analysis of cDNA sequences.
  • Comparison with expressed sequence tags (ESTs).
  • Analysis of human and chimpanzee genomic sequences.

Main Results:

  • The existence of the AD7c-NTP gene and its predicted protein is inconsistent with available EST and genomic data.

Related Experiment Videos

  • Discrepancies were found when comparing the published cDNA sequence to genomic and EST sequences.

    • Conclusions:

    • The previously reported findings on AD7c-NTP require reassessment.
    • The genetic basis for AD7c-NTP and its role in Alzheimer's disease warrant further investigation.