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Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Antifungal sesquiterpene from the root of Vernonanthura tweedieana
Aida Portillo1, Roser Vila, Blanca Freixa
1Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain.
Abstract:
The bioassay-guided fractionation of the antifungal dichloromethane extract from the roots of Vernonanthura tweedieana (Baker) H. Rob. (Asteraceae), using an agar overlay bioautographic method, allowed the isolation of one active sesquiterpene (1), identified as 6-cinnamoyloxy-1-hydroxyeudesm-4-en-3-one. Minimal inhibitory concentrations (MIC) and minimal fungicidal concentrations (MFC) of 1 showed Trichophyton mentagrophytes as the most sensitive strain, with the same MIC and MFC values (4 microg/ml).
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