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FT-IR spectrophotometric analysis of dehydroepiandrosterone and its pharmaceutical formulation
Andrei A Bunaciu1, Hassan Y Aboul-Enein, Serban Fleschin
1ROMSPECTRA IMPEX SRL, Analytical Research Department, 25 Str. Maguricea, P.O. Box 52, Bucharest 3, Romania.
Abstract:
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of dehydropeiandrosterone. Conventional KBr spectra and KBr + 2.0 mg microcrystalline cellulose (MCC) spectra were compared for best determination of active substance in drug formulation. Two chemometric approaches, partial least-squares (PLS) and principal component regression (PCR+) methods were used in data processing. The best results were obtained with PCR+ method.
