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Published on: August 12, 2015
Differential pulse voltammetric determination of carvedilol in tablets dosage form using glassy carbon electrode
1Department of Chemistry, Faculty of Science, Mansoura University, 34517 Dumyat, Egypt. abdradi@yahoo.com
Abstract:
The electrochemical oxidation of antihypertensive drug carvedilol has been studied in pH range 2.0-11.0 at a glassy carbon electrode by cyclic and differential pulse voltammetry. Two oxidation processes were produced in different supporting electrolyte media. Both oxidation processes were irreversible and diffusion-controlled. The first oxidation process was chosen for the analysis of carvedilol. A very resolved voltammetric peak was obtained in Britton-Robinson buffer at pH 8.0 using differential pulse mode. The linear response was obtained in the range of 0.25-10.00 microg ml(-1). The limit of detection was found to be 0.10 microg ml(-1). The developed method was used for the determination of carvedilol in tablet dosage form.
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