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Related Concept Videos

Factors Affecting Solubility04:01

Factors Affecting Solubility

Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

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Related Experiment Video

Updated: Jun 7, 2026

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)
09:32

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)

Published on: May 7, 2013

Redoxing calcium from the ER.

H Llewelyn Roderick1, Martin D Bootman

  • 1Laboratory for Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT, United Kingdom.

Cell
|January 18, 2005
PubMed
Summary
This summary is machine-generated.

Inositol 1,4,5-trisphosphate (InsP3)-induced calcium release is vital for cellular functions. A new study reveals the InsP3 receptor is regulated by the endoplasmic reticulum

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Related Experiment Videos

Last Updated: Jun 7, 2026

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)
09:32

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)

Published on: May 7, 2013

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
08:41

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

Published on: September 6, 2015

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
12:30

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Published on: May 19, 2017

Area of Science:

  • Cellular biology
  • Molecular physiology
  • Calcium signaling

Background:

  • Inositol 1,4,5-trisphosphate (InsP3) mediated calcium release from the endoplasmic reticulum (ER) is a fundamental cellular process.
  • This signaling pathway regulates critical cellular functions throughout an organism's life.

Discussion:

  • Mikoshiba and colleagues have identified a novel regulatory mechanism for the InsP3 receptor (InsP3R).
  • This regulation is influenced by the redox state, calcium concentration, and pH within the ER lumen.

Key Insights:

  • The InsP3 receptor's activity is modulated by the ER luminal environment.
  • This finding provides new insights into the complex control of intracellular calcium release.

Outlook:

  • Further research may elucidate the precise molecular mechanisms of this novel regulation.
  • Understanding this pathway could have implications for various physiological and pathological conditions involving calcium signaling.