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Related Experiment Videos

Anosognosia during Wada testing.

R L Gilmore1, K M Heilman, R P Schmidt

  • 1Departments of Neurology, College of Medicine, University of Florida, Gainesville 32610.

Neurology
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

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Anosognosia, or denial of paralysis, is more common after right-hemisphere brain damage. This study suggests it is linked to right-hemisphere dysfunction, not psychological denial.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Anosognosia (denial of hemiplegia) is frequently reported after right-hemisphere lesions.
  • Its higher incidence with right-hemisphere damage may be confounded by aphasia in left-hemisphere lesions.
  • Previous theories attributed anosognosia to psychological denial or emotional changes.

Purpose of the Study:

  • To investigate the hemispheric lateralization of anosognosia.
  • To differentiate anosognosia from psychological denial and emotional changes.

Main Methods:

  • Eight epilepsy patients undergoing Wada testing (intracarotid methohexital injection) were assessed.
  • Anosognosia was evaluated after temporary anesthesia of either the left or right hemisphere.
  • Patients recalled motor and language deficits after anesthesia cleared.

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Main Results:

  • Following left-hemisphere anesthesia, all patients recalled both hemiplegia and aphasia.
  • After right-hemisphere anesthesia, none of the eight patients recalled their hemiplegia.
  • This dissociation was consistent across all participants.

Conclusions:

  • Anosognosia is more strongly associated with right-hemisphere dysfunction than left-hemisphere dysfunction.
  • The findings argue against psychological denial or emotional changes as the primary cause of anosognosia.
  • Hemispheric lateralization plays a critical role in the manifestation of anosognosia.