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Updated: Aug 20, 2026
Establishment of an Embryo Implantation Model In Vitro
Published on: June 21, 2024
Use of a prediction model for high-order multiple implantation after ovarian stimulation with gonadotropins
Rosa Tur1, Pedro N Barri, Buenaventura Coroleu
1Reproductive Medicine Service, Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Barcelona, Spain. rostur@dexeus.com
Objective:
To determine prospectively the effectiveness in clinical practice of a prediction model for high-order multiple pregnancies (HOMP) (triplets or more).
Design:
Prospective study.
Setting:
University teaching hospital.
Patient(S):
Eight hundred forty-nine consecutive infertile patients undergoing a total of 1,542 treatment cycles.
Intervention(S):
Gonadotropin ovarian stimulation or induction of ovulation without IVF MAIN OUTCOME MEASURE(S): Observed and predicted overall pregnancy rates and the incidence of HOMP.
Result(S):
The use of the prediction model (implying cancellation of all cycles at high risk for HOMP) would result in an 8% (95% confidence interval, 6.8%-9.2%) reduction of overall pregnancy rate but also in a 285% (95% CI, 279%-291%) reduction of HOMP.
Conclusion(S):
By using our prediction model, it was possible to maintain a low risk of HOMP with a good pregnancy rate in patients receiving gonadotropin ovarian stimulation or induction of ovulation without IVF.
Related Concept Videos
01:27Ovarian Cycle
01:24In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...