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Analysis of Retinoic Acid-induced Neural Differentiation of Mouse Embryonic Stem Cells in Two and Three-dimensional Embryoid Bodies
Published on: April 22, 2017
Effects of retinoic acid on the inner cell mass in mouse blastocysts
Fu-Jen Huang1, Yu-Cheng Hsu, Hong-Yo Kang
1Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Fertility and Sterility
|January 18, 2005
Abstract:
This is the first evidence that excess retinoic acid has a direct cellular response from proliferation to cell death (apoptosis) and affects in vitro development in mouse inner cell mass.
Insights
Excess retinoic acid directly impacts mouse inner cell mass development. This study shows its role in cellular processes from proliferation to apoptosis.
Area of Science:
- Developmental Biology
- Cell Biology
- Toxicology
Background:
- Retinoic acid is crucial for embryonic development.
- Understanding its precise effects on early development is essential.
Purpose of the Study:
- To investigate the direct cellular responses to excess retinoic acid.
- To determine the impact of excess retinoic acid on in vitro development of mouse inner cell mass.
Main Methods:
- In vitro culture of mouse inner cell mass.
- Exposure to excess retinoic acid.
- Assessment of cellular proliferation and apoptosis.
Main Results:
- Excess retinoic acid elicits direct cellular responses.
- Observed effects range from increased proliferation to induction of apoptosis.
- In vitro development of mouse inner cell mass is significantly affected.
Conclusions:
- This study provides the first evidence of direct cellular responses to excess retinoic acid.
- Excess retinoic acid influences key cellular processes including proliferation and apoptosis.
- These findings highlight the critical role of retinoic acid concentration in early embryonic development.
