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Hemispheric asymmetry, modular variability and age-related changes in the human entorhinal cortex.

G Simic1, S Bexheti, Z Kelovic

  • 1Department of Neuroscience, Croatian Institute for Brain Research, Zagreb University Medical School, Salata 12, Zagreb 10000, Croatia. gsimic@hiim.hr

Neuroscience
|January 18, 2005
PubMed
Summary
This summary is machine-generated.

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The human entorhinal cortex shows age-related neuron loss, with larger areas and more neurons in the left hemisphere. This brain region

Area of Science:

  • Neuroscience
  • Human Anatomy
  • Aging Research

Background:

  • The verrucae areae entorhinalis (VAE) are crucial brain structures in the parahippocampal gyri, characterized by islands of layer II neurons.
  • These areas are implicated in memory processing and are among the first affected by neurofibrillary changes during aging.

Purpose of the Study:

  • To investigate age-related changes in the verrucae areae entorhinalis (VAE) in the human brain.
  • To analyze neuronal number, surface area, and hemispheric asymmetry within the entorhinal cortex.

Main Methods:

  • Analysis of VAE in 60 neurologically normal subjects (23-85 years old) using a casting method.
  • Stereological estimation of neuron numbers in entorhinal islands using the optical fractionator in 10 subjects.

Related Experiment Videos

Main Results:

  • A significant leftward asymmetry in VAE number and surface area was observed.
  • A significant negative correlation between VAE area and age was found, indicating neuron loss.
  • No significant difference in total neuron number between hemispheres, but a significant negative correlation with age.
  • Frequent observation of heterotopias (clusters of small neurons) in the rostral entorhinal cortex.

Conclusions:

  • The study confirms age-related neuron loss in the entorhinal cortex.
  • Leftward asymmetry in VAE suggests potential functional lateralization for language-related memory processing.
  • Findings align with the left hippocampus's role in verbal episodic memory.