Related Experiment Video

Updated: Aug 20, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

[Severe acute pancreatitis in children receiving asparaginase: multicenter retrospective study]

V Laugel1, B Escande, N Entz-Werle

  • 1Service d'oncohématologie pédiatrique, hôpital de Hautepierre, CHU de Strasbourg, avenue Molière, 67098 Strasbourg cedex, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|January 18, 2005
PubMed

Insights

Asparaginase treatment for childhood lymphoblastic malignancies can cause severe acute pancreatitis. Intensive supportive care is crucial for favorable outcomes, and reintroducing asparaginase is not recommended due to recurrence risks.

Area of Science:

  • Pediatric oncology
  • Gastroenterology
  • Toxicology

Context:

  • Asparaginase is a key chemotherapeutic agent for pediatric lymphoblastic malignancies.
  • Drug-induced acute pancreatitis is a significant, though uncommon, adverse effect of asparaginase therapy.
  • Severe cases of asparaginase-induced pancreatitis pose diagnostic and therapeutic challenges in pediatric patients.

Purpose:

  • To retrospectively analyze pediatric cases of severe acute pancreatitis induced by asparaginase.
  • To identify the clinical presentation, complications, and management strategies for asparaginase-induced pancreatitis.
  • To evaluate the outcomes and recurrence risks associated with asparaginase re-administration.

Summary:

  • Eleven pediatric patients (4-15 years) developed severe acute pancreatitis after 6-21 doses of asparaginase.
  • Major complications included circulatory collapse, insulin-dependent diabetes, and pancreatic pseudocysts.
  • Management involved digestive rest, antibiotics, and morphine; re-challenge with asparaginase led to recurrence in two of three cases.

Impact:

  • Intensive supportive management can lead to favorable outcomes in most pediatric cases of asparaginase-induced pancreatitis.
  • Predicting the occurrence of this adverse event is not currently possible.
  • The study suggests that re-use of asparaginase should be avoided to prevent pancreatitis recurrence.
Abstract

More Related Videos

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...