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Fabrication of monodispersed Taxol-loaded particles using electrohydrodynamic atomization
Luna Ding1, Timothy Lee, Chi-Hwa Wang
1Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore.
Summary
Electrohydrodynamic atomization (EHDA) effectively produces uniform Taxol-loaded poly-caprolactone (PCL) particles for controlled drug release. Yields were improved to 80% by optimizing ventilation and charge dissipation, enabling sustained drug delivery.
Area of Science:
- Materials Science
- Pharmaceutical Technology
- Biomedical Engineering
Background:
- Monodispersed particles are crucial for uniform controlled drug release.
- Electrohydrodynamic atomization (EHDA) shows potential for producing particles with low polydispersity.
Purpose of the Study:
- To fabricate Taxol-loaded poly-caprolactone (PCL) particles using EHDA.
- To investigate and improve the low yield of the EHDA method.
- To characterize the fabricated particles for drug delivery applications.
Main Methods:
- Particle fabrication via Electrohydrodynamic atomization (EHDA).
- Yield improvement through enhanced ventilation and charge dissipation.
- Characterization using Phase Doppler Particle Analyzer (PDPA), Differential Scanning Calorimetry (DSC), and laser confocal microscopy.
Main Results:
- EHDA successfully produced Taxol-loaded PCL particles with near-monodispersed sizes.
- EHDA yield was improved to approximately 80% by optimizing operating conditions.
- Particles exhibited high encapsulation efficiency and sustained release over one month, with moderate zeta potential correlating to in vitro cell uptake.
Conclusions:
- EHDA is a promising technique for fabricating monodispersed drug delivery particles.
- Optimized EHDA parameters enhance particle production yield and quality.
- The fabricated particles demonstrate potential for effective controlled drug release applications.