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Published on: May 23, 2021
Fetal arrhythmias: natural history and management
Patrizia Vergani1, Eloisa Mariani, Elena Ciriello
1Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy. pvergani@yahoo.it
Insights
Fetal arrhythmias detected via prenatal ultrasound screening have a 0.3% incidence. While most fetal tachyarrhythmias have a good prognosis, bradyarrhythmias are less favorable, with survival dependent on type and associated anomalies.
Area of Science:
- Cardiology
- Prenatal Medicine
- Pediatrics
Background:
- Fetal arrhythmias are detected during prenatal screening.
- Understanding their natural history and management is crucial.
Purpose of the Study:
- To delineate the significance and natural history of fetal arrhythmias.
- To provide information on the management of fetal arrhythmias.
- To assess outcomes of fetuses with arrhythmias.
Main Methods:
- A cohort of 114 infants with fetal arrhythmias identified via prenatal ultrasound.
- Echocardiography and clinically indicated treatment were administered.
- Postnatal outcomes were tracked for 1 year.
Main Results:
- The incidence of fetal arrhythmias was 0.3%.
- Atrial extrasystoles led to supraventricular tachycardia (SVT) in 2.3% of fetuses.
- In utero antiarrhythmic therapy (digoxin, propafenone) successfully restored sinus rhythm in 100% of SVT cases.
- Sinus bradycardia was linked to structural anomalies; only 2 of 4 fetuses with atrioventricular block survived.
Conclusions:
- Prognosis for most fetal tachyarrhythmias is favorable.
- Bradyarrhythmias, particularly atrioventricular block, carry a less favorable prognosis.
- Early detection and management of fetal arrhythmias are vital for improved outcomes.
Abstract:
The aim was to delineate the significance and natural history of fetal arrhythmias and provide information about their management. A cohort of 114 infants with fetal arrhythmias detected during prenatal ultrasound (US) screening were studied. All subjects underwent echocardiography and were treated as clinically indicated. Postnatal outcome was obtained in 100% of infants until 1 year of age. The incidence of fetal arrhythmias was 0.3%. Among the 87 fetuses with atrial extrasystoles, 2.3% developed supraventricular tachycardia (SVT) in utero. Of the 10 SVT cases, only five required antiarrhythmic therapy in utero with digoxin and propafenone, which successfully restored sinus rhythm in 100% of fetuses, both nonhydropic and hydropic. Sinus bradycardia was associated with structural anomalies in 5 of 6 patients and only 2 of 4 fetuses with atrioventricular block survived. It is concluded that prognosis is good for most fetal tachyarrhythmias, whereas it is less favorable for bradyarrhythmias.
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