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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase
Ya-ming Xu1, Randall K Johnson, Sidney M Hecht
1Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA.
Bioorganic & Medicinal Chemistry
|January 18, 2005
Abstract:
Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2',4'-dibromophenoxy)phenol (1) and 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.