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Updated: Aug 20, 2026

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
Published on: October 8, 2015
Structural flexibility of small GTPases. Can it explain their functional versatility?
1The Biocenter of the University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. e.helmreich@mail.uni-wuerzburg.de
Abstract:
Multiple interactions with many different partners are responsible for the amazing functional versatility of proteins, especially those participating in cellular regulation. The structural properties that could facilitate multiple interactions are examined for small GTPases. The role of cellular constraints, compartmentation and scaffolds on protein-protein interactions is considered.
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