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Related Experiment Videos

Limb anomalies associated with chorionic villus sampling.

B K Burton1, C J Schulz, L I Burd

  • 1Center for Medical and Reproductive Genetics, Humana Hospital-Michael Reese, Chicago, Illinois.

Obstetrics and Gynecology
|May 1, 1992
PubMed
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Chorionic villus sampling (CVS) may increase the risk of limb anomalies in fetuses. Further research is needed to understand the vascular causes of these congenital anomalies.

Area of Science:

  • Medical Genetics
  • Prenatal Diagnosis
  • Obstetrics

Background:

  • Chorionic villus sampling (CVS) is a common prenatal diagnostic technique.
  • Previous studies have raised concerns about potential risks associated with CVS.

Purpose of the Study:

  • To evaluate the pregnancy outcomes of patients who underwent chorionic villus sampling.
  • To identify and characterize major congenital anomalies in infants following CVS.

Main Methods:

  • Retrospective analysis of 463 patients undergoing CVS between January 1989 and November 1990.
  • Data collection on pregnancy outcomes, including fetal and neonatal losses and surviving infants.
  • Evaluation of surviving infants for major congenital anomalies.

Main Results:

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  • 13 out of 394 adequately evaluated fetuses and infants (3.3%) had major congenital anomalies.
  • Four infants presented with transverse limb reduction deformities, similar to those previously associated with CVS.
  • Three cases of limb malformations occurred after transcervical CVS, one after transabdominal CVS.

Conclusions:

  • The findings suggest an increased risk of limb anomalies associated with chorionic villus sampling.
  • A potential vascular etiology, such as decreased fetal perfusion or thrombosis, is proposed.
  • Further investigation into the relationship between CVS and limb malformations is warranted.