Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution.

Xionglei He1, Jianzhi Zhang

  • 1Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.

Genetics
|January 18, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: 'In search of the genetic variants of human sex ratio at birth: was Fisher wrong about sex ratio evolution?' (2024), by Song & Zhang.

Proceedings. Biological sciences·2026
Same author

Longitudinal lineage tracing reveals early clonal attrition during Drosophila midgut aging.

PLoS biology·2026
Same author

Rapid evolution driven by translocation-associated selection during meiosis.

EMBO reports·2026
Same author

Comprehensive analysis based on tertiary lymphoid structures and tumor budding predicts survival rates in colorectal cancer patients with synchronous liver metastases.

Frontiers in immunology·2026
Same author

A comprehensive single-cell atlas of monoallelic expression across various tissues in zebrafish.

Genome research·2026
Same author

An interpretable machine learning model for predicting NICU admission in preterm infants: a single-center retrospective cohort study.

Translational pediatrics·2026

Gene duplication creates new genes. A new model, subneofunctionalization (SNF), shows duplicate genes rapidly undergo subfunctionalization and prolonged neofunctionalization, explaining genome-wide patterns.

Area of Science:

  • Evolutionary genetics
  • Genomics
  • Molecular biology

Background:

  • Gene duplication is a major source of novel genes in genomes.
  • The functional divergence of duplicate genes is not fully understood, with competing neofunctionalization (NF) and subfunctionalization (SF) hypotheses.
  • Existing models inadequately explain genome-wide patterns of duplicate gene function.

Purpose of the Study:

  • To investigate the mechanisms of functional divergence in duplicate genes.
  • To test the explanatory power of neofunctionalization and subfunctionalization hypotheses.
  • To propose a new model for duplicate gene evolution.

Main Methods:

  • Analysis of genome-wide yeast protein interaction data.
  • Examination of human gene expression patterns for duplicate genes.

Related Experiment Videos

  • Comparative analysis of evolutionary models.

    • Main Results:

    • Neither neofunctionalization nor subfunctionalization alone sufficiently explains observed patterns.
    • Rapid subfunctionalization coupled with prolonged neofunctionalization is prevalent in duplicate genes.
    • A new model, subneofunctionalization (SNF), better accounts for genome-wide data.

    Conclusions:

    • The evolution of duplicate genes is more complex than previously modeled.
    • Subneofunctionalization (SNF) provides a more comprehensive framework for understanding gene duplication.
    • Gene duplication is a significant driver of functional innovation in genomes.