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Updated: Aug 11, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Paraneoplastic neurologic syndrome and autoimmune Addison disease in a patient with thymoma
Hiroyuki Morita1, Takuo Hirota, Tomoatsu Mune
1Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan. hmorita@cc.gifu-u.ac.jp
Abstract:
A 48-year-old man with autoimmune Addison disease developed the following paraneoplastic neurologic syndromes (PNNS): limbic encephalitis, opsoclonus/myoclonus, and sensorimotor and autonomic neuropathies. An anterior mediastinal mass detected on a chest computed tomographic scan was found on resection to be a noninvasive lymphocytic thymoma. The PNNS went into remission 1 year after the thymectomy. This is the first case of thymoma associated with autoimmune Addison disease and PNNS to be described in the literature.
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