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Updated: Aug 19, 2026
Real-time Cytotoxicity Assays in Human Whole Blood
Published on: November 7, 2014
Ramipril-induced agranulocytosis confirmed by a lymphocyte cytotoxicity test
Nathaniel Horowitz1, Madlen Molnar, Yishai Levy
1Department of Internal Medicine D and the Immunology and Allergy Institute, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. n_horowitz@rambam.health.gov.il
Abstract:
A 50-year-old man who had chronic renal failure presented with neutropenic fever four days after ramipril was initiated. Agranulocytosis due to other causes was ruled out after a bone marrow aspiration and biopsy examination were performed. A relationship between the drug and the adverse effect was suggested. It was established by a novel lymphocyte cytotoxicity test.
