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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Plasma soluble adhesion molecules; intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and

Hasan Turhan1, Ali Riza Erbay, Ayse Saatci Yasar

  • 1Inonu University Medical Faculty, Department of Cardiology, Malatya, Turkey.

Coronary Artery Disease
|January 18, 2005
PubMed

Insights

Patients with isolated coronary artery ectasia (CAE) exhibit elevated levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. This indicates a more severe chronic inflammation in the coronary arteries of CAE patients.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Biomarker Discovery

Background:

  • Coronary artery ectasia (CAE) often coexists with coronary artery disease (CAD), suggesting a potential link.
  • The underlying mechanisms driving CAE development in some obstructive CAD patients remain unclear.
  • Inflammation is implicated in both obstructive and aneurysmal vascular conditions.

Purpose of the Study:

  • To investigate plasma levels of soluble adhesion molecules—intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin—in patients with isolated CAE.
  • To compare these levels between isolated CAE patients, obstructive CAD patients without CAE, and healthy controls.

Main Methods:

  • The study included 32 patients with isolated CAE, 32 with obstructive CAD (no CAE), and 30 healthy controls.
  • Quantitative coronary angiography was used to define and measure coronary artery ectasia.
  • Plasma levels of ICAM-1, VCAM-1, and E-selectin were quantified using enzyme-linked immunosorbent assay (ELISA) kits.

Main Results:

  • Patients with isolated CAE showed significantly higher plasma levels of ICAM-1, VCAM-1, and E-selectin compared to both obstructive CAD patients and controls (P < 0.001 for ICAM-1 and VCAM-1 vs. both groups; P = 0.01 for E-selectin vs. obstructive CAD, P < 0.001 vs. controls).
  • A positive correlation was observed between the length of ectasic segments and levels of ICAM-1, VCAM-1, and E-selectin.
  • Multivariate analysis identified a significant independent association between isolated CAE and elevated ICAM-1 (OR=1.023, P=0.0129) and VCAM-1 (OR=1.0057, P=0.0240).

Conclusions:

  • Patients with isolated coronary artery ectasia exhibit significantly elevated plasma levels of ICAM-1, VCAM-1, and E-selectin.
  • These findings suggest a more severe and widespread chronic inflammatory process in the coronary circulation of individuals with isolated CAE.
  • Soluble adhesion molecules may serve as important biomarkers for inflammation in coronary artery ectasia.
Abstract

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