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Published on: May 15, 2019
A case of disseminated Langerhans' cell histiocytosis treated with thalidomide
E Mauro1, C Fraulini, G M Rigolin
1Section of Hematology, Department of Biomedical Sciences, University of Ferrara, Ferrara, Italy.
European Journal of Haematology
|January 19, 2005
Abstract:
Tumor necrosis factor alpha (TNF-alpha) seems to play a key role in the pathogenesis of Langerhans' cell histiocytosis (LCH). Thalidomide is an immunomodulator agent of inflammatory cytokines including TNF-alpha. To our knowledge this is the first case of disseminated LCH successfully treated with thalidomide.