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Association between mitral annular calcification and stroke

Ayşe Tunca1, Aydin Karanfil, Asli Köktener

  • 1Department of Neurology, Fatih University Medical School, Ankara, Turkey.

Japanese Heart Journal
|January 19, 2005
PubMed

Insights

Mitral annular calcification (MAC) is associated with carotid artery atherosclerosis, a secondary risk factor for stroke. This finding suggests MAC may not directly cause stroke but contributes to stroke risk through arterial disease.

Area of Science:

  • Cardiology
  • Neurology
  • Radiology

Background:

  • Mitral annular calcification (MAC) is a debated independent predictor of stroke.
  • Understanding the relationship between MAC and stroke is crucial for risk stratification.

Purpose of the Study:

  • To investigate the association between MAC and stroke.
  • To determine if MAC is a predictive factor for carotid atheroma, thus a secondary stroke risk.

Main Methods:

  • Echocardiography to identify MAC in 56 patients.
  • Carotid artery duplex sonography and computed brain tomography in MAC patients and 58 controls.
  • Analysis of MAC, carotid atheroma, stenosis, and cerebral ischemia.

Main Results:

  • Significant associations found between MAC and carotid atheroma (P=0.011), hyperechogenic plaque (P=0.034), and stenosis (P=0.008).
  • Carotid atheroma was associated with cerebral infarction (P=0.007).
  • Hypertension and diabetes were independent risk factors for carotid atheroma; MAC was an independent factor for carotid stenosis (P=0.029).

Conclusions:

  • MAC may be a secondary, not a primary, risk factor for stroke.
  • The association between MAC and carotid artery atherosclerotic disease may explain the high stroke prevalence in MAC patients.

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