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Monitoring expression of cytochrome P450 genes during postischemic rat liver reperfusion using DNA microarrays

Yasuo Takahashi1, Yayoi Nishida, Yukimoto Ishii

  • 1Division of Genomic Epidemiology & Clinical Trials, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan.

Journal of Pharmacological Sciences
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PubMed

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...