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Shigellosis in Thai children: epidemiologic, clinical and laboratory features
U S Thisyakorn1, S Rienprayoon
1Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Abstract:
Two hundred thirty cases of shigellosis in children managed at Chulalongkorn Hospital from 1984 to 1988 were reviewed. The most common presentation included diarrhea, most frequently with mucus and blood, and fever. There were no deaths. The most common species was Shigella flexneri (83.5%) which showed increasing resistance to trimethoprim-sulfamethoxazole.
Insights
Shigellosis in children commonly presents with bloody diarrhea and fever. Shigella flexneri was the most common cause, exhibiting growing resistance to trimethoprim-sulfamethoxazole.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Shigellosis is a significant cause of diarrheal disease in children worldwide.
- Understanding local epidemiological patterns and antimicrobial resistance is crucial for effective management.
Purpose of the Study:
- To review cases of shigellosis in children managed at a specific hospital.
- To identify common clinical presentations and causative species.
- To assess antimicrobial resistance patterns over time.
Main Methods:
- Retrospective review of 230 pediatric shigellosis cases.
- Data collected from Chulalongkorn Hospital between 1984 and 1988.
- Analysis of clinical features, causative Shigella species, and antibiotic susceptibility.
Main Results:
- Diarrhea, often bloody and mucoid, accompanied by fever, was the most frequent presentation.
- Shigella flexneri accounted for 83.5% of infections.
- An increasing resistance to trimethoprim-sulfamethoxazole was observed in Shigella flexneri isolates.
Conclusions:
- Shigellosis in children typically presents with dysentery and fever.
- Shigella flexneri is the predominant species, necessitating monitoring of its antimicrobial susceptibility.
- The rising resistance to trimethoprim-sulfamethoxazole highlights the need for updated treatment guidelines.