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BDNF in schizophrenia, depression and corresponding animal models
F Angelucci1, S Brenè, A A Mathé
1Institute of Neurology, Catholic University, Largo Gemelli, Rome, Italy.
Molecular Psychiatry
|January 19, 2005
Summary
Schizophrenia and depression may stem from neurotrophic factor dysfunction. This review examines Brain-Derived Neurotrophic Factor (BDNF) alterations in these disorders and treatment impacts.
Area of Science:
- Neuroscience
- Psychiatry
- Molecular Biology
Background:
- Schizophrenia and depression pathogenesis remain challenging psychiatric research areas.
- Neurotrophic factors, crucial for neuronal development and function, are hypothesized to be dysfunctional in these disorders.
- Impaired neurotrophic support can lead to developmental brain disorganization and reduced adult adaptive capacity.
Purpose of the Study:
- To review the role of Brain-Derived Neurotrophic Factor (BDNF) in schizophrenia and depression.
- To summarize findings on altered BDNF levels in human patients and animal models.
- To explore the impact of antipsychotic and antidepressant treatments on BDNF expression.
Main Methods:
- Literature review of studies investigating BDNF in schizophrenia and depression.
- Analysis of data from animal models of these psychiatric conditions.
- Examination of research on the effects of pharmacological treatments on BDNF.
Main Results:
- Altered levels of BDNF are observed in individuals with schizophrenia and depression.
- Animal models show changes in BDNF that correlate with disease phenotypes.
- Antipsychotic and antidepressant treatments can modulate BDNF expression.
Conclusions:
- BDNF is implicated in the pathophysiology of schizophrenia and depression.
- BDNF levels and their regulation by treatments offer potential therapeutic targets.
- Further research into BDNF's role is critical for advancing psychiatric treatment.