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Locally recurrent rectal cancer after curative resection
E Christoforidis1, I Kanellos, T Tsachalis
14th Surgical Department, Aristotle University, Thessaloniki, Greece. emmch@auth.gr
Techniques in Coloproctology
|January 19, 2005
Summary
Total mesorectal excision (TME) significantly reduces local recurrence in rectal cancer patients. This surgical technique, combined with other factors, leads to a low incidence of local relapse after curative resection.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Surgery
Background:
- Rectal cancer management involves curative resection.
- Local recurrence remains a significant concern post-surgery.
- Total mesorectal excision (TME) is a key surgical technique.
Purpose of the Study:
- To determine the incidence of local recurrence after curative resection for rectal cancer.
- To evaluate the role of Total Mesorectal Excision (TME) in reducing local recurrence.
Main Methods:
- A cohort of 120 patients undergoing curative resection for rectal cancer over ten years was analyzed.
- Total Mesorectal Excision (TME) was routinely applied, except in high anterior resections.
- Factors assessed for local relapse included TME, preoperative radiotherapy, tumor stage, differentiation grade, and lymph node status.
Main Results:
- The local recurrence rate was 6.7% (8 patients).
- At 5 years, 91.9% of patients were free of local recurrence, with an 81% actuarial disease-free survival.
- Routine TME, tumor stage, differentiation grade, and lymph node invasion were significantly associated with local recurrence; preoperative radiotherapy showed no protective effect.
Conclusions:
- Curative resection of rectal cancer using TME results in a very low incidence of local relapse.
- TME is a critical component in minimizing local recurrence for rectal cancer.
- Further research may explore the role of preoperative radiotherapy in conjunction with TME.