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Updated: Jul 1, 2026

Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models
08:43

Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models

Published on: January 14, 2020

[Pathogenesis of the ductal pancreatic adenocarcinoma: implications for future therapies?]

G Schneider1, R M Schmid

  • 1II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München.

Der Internist
|January 19, 2005
PubMed

Insights

Pancreatic cancer has poor survival rates despite molecular advances. This review details cancer cell cycle, apoptosis, invasion, and angiogenesis to guide new therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Context:

  • Pancreatic cancer has a dismal 5-year survival rate (<5%) despite progress in understanding its molecular pathogenesis.
  • Current treatments for pancreatic cancer are largely ineffective in improving overall survival.
  • A significant gap exists between basic science discoveries and their translation into effective therapeutic strategies.

Purpose:

  • To review the key molecular mechanisms driving pancreatic cancer progression.
  • To elucidate disturbed cell cycle control, anti-apoptotic pathways, invasion, metastasis, and angiogenesis in pancreatic cancer.
  • To provide a foundation for developing novel therapeutic interventions.

Summary:

  • This review examines critical molecular alterations in pancreatic cancer, including dysregulated cell cycle control, evasion of apoptosis, and promotion of invasion, metastasis, and angiogenesis.
  • Understanding these fundamental processes is crucial for identifying new therapeutic targets.
  • The review synthesizes current knowledge on the molecular pathogenesis of pancreatic cancer.

Impact:

  • Facilitates the development of innovative therapeutic strategies for pancreatic cancer.
  • Aims to improve treatment outcomes and patient survival rates.
  • Bridges the gap between basic research and clinical application in pancreatic cancer therapy.

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