Related Experiment Video
Updated: Aug 20, 2026

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Published on: February 26, 2019
Gastrointestinal hormones and regulation of food intake
1Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 ONN, UK.
Abstract:
Obesity has been described as the greatest current threat to human health. In order to design drugs to target obesity, it is essential to understand its physiology and pathophysiology. Several peptides synthesised in the gastrointestinal tract which affect food intake have been identified including ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (7-36) amide (GLP-1), oxyntomodulin, peptide YY (PYY) and pancreatic polypeptide (PP). These peptides represent potential targets for the design of anti-obesity drugs. In this article we review recent advances in our understanding of food intake by these gastrointestinal hormones.
More Related Videos
Related Concept Videos
Hormonal Regulation
Hormonal Regulation
Regulation of Food Intake
Regulation of the Digestive System
The effectors in this regulation system are glands and smooth muscles. Activation of these...
Hormones Secreted by the Stomach
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
Neural Regulation

