Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrastructural changes in non-specific duodenitis.

Cheng-Xin Wang1, Li-Jiang Liu, Jing Guan

  • 1Department of Pathology and Pathophysiology, School of Medicine and Life Sciences, Jianghan University, Wuhan 430056, Hubei Province, China. wangchengxin2000@yahoo.com.cn

World Journal of Gastroenterology
|January 19, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term effectiveness and safety of vedolizumab in ulcerative colitis: a real-world retrospective cohort study over 2 years.

Frontiers in medicine·2026
Same author

Mitophagy in inflammatory bowel disease: regulatory mechanisms and therapeutic potential.

Frontiers in cell and developmental biology·2026
Same author

Audiological Phenotype, Natural History, and Intervention in Chinese Patients With Auditory Neuropathy Caused by OTOF Variants.

Ear and hearing·2026
Same author

Research on strategies for enhancing the competency of safety directors in EPC projects empowered by AI.

PloS one·2026
Same author

Surveillance for invasive candidiasis in China (CHIF-NET 2018-2021): rising antifungal resistance observed in a nationwide longitudinal study.

Antimicrobial agents and chemotherapy·2026
Same author

Investigation of molecular immune regulation mechanisms and therapeutic target prediction in pancreatic cancer based on bioinformatics and genetics.

Clinics (Sao Paulo, Brazil)·2026
Same journal

Lessons from extended induction and practical evidence for improving tofacitinib therapy in ulcerative colitis.

World journal of gastroenterology·2026
Same journal

Small animal <i>ex vivo</i> machine perfusion of the liver: A comprehensive literature review.

World journal of gastroenterology·2026
Same journal

Comparable remission and health care use in real-world inflammatory bowel disease patients initiating originator biologics <i>vs</i> biosimilars.

World journal of gastroenterology·2026
Same journal

Diagnosis and management of metabolic dysfunction-associated steatohepatitis in patients with chronic hepatitis B infection.

World journal of gastroenterology·2026
Same journal

Simultaneous treatment of concomitant achalasia coexisting with epiphrenic diverticulum: The practice of submucosal tunneling technique.

World journal of gastroenterology·2026
Same journal

Lianhe Xiaozhi ointment ameliorates metabolic dysfunction-associated steatotic liver disease <i>via</i> peroxisome proliferator-activated receptor alpha pathway activation.

World journal of gastroenterology·2026
See all related articles

Scanning electron microscopy (SEM) reveals distinct ultrastructural changes in non-specific duodenitis (NSD), aiding in grading disease severity and diagnosing duodenal mucosal conditions.

Area of Science:

  • Gastroenterology
  • Pathology
  • Microscopy

Background:

  • Non-specific duodenitis (NSD) is a common gastrointestinal condition.
  • Accurate grading of NSD is crucial for effective patient management.
  • Existing diagnostic methods may not fully capture the morphological complexity of NSD.

Purpose of the Study:

  • To investigate the ultrastructural and morphological changes in non-specific duodenitis.
  • To grade NSD lesions based on the extent of observed changes.
  • To evaluate the utility of scanning electron microscopy (SEM) in diagnosing duodenal mucosal diseases.

Main Methods:

  • Biopsies from the duodenal bulb mucosa of 44 patients with epigastric discomfort were obtained.
  • Samples were analyzed using light microscopy (hematoxylin-eosin, Warthin-Starry silver) and scanning electron microscopy (SEM).

Related Experiment Videos

  • Histological grading (normal, mild, moderate, severe NSD) was correlated with SEM findings.

    • Main Results:

    • SEM enabled classification of NSD into normal, mild, moderate, and severe degrees based on ultrastructural changes.
    • Observed changes included inflammation, erosion, desquamation, and ulcer-like defects on epithelial cells.
    • Gastric metaplasia was present in 25% of cases, and Helicobacter pylori infection in 41.67%.

    Conclusions:

    • Non-specific duodenitis is a distinct disease entity with diverse etiologies.
    • SEM provides valuable insights into duodenal mucosal morphology.
    • SEM serves as an effective aid in diagnosing mucosal diseases of the duodenum.